Protein Modules and Signaling Networks

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Fibroblast growth factors, their receptors and signaling. (2000, background): “One way these recruited target proteins may be localized to the activated receptor is through the interaction between their Src-homology 2 (SH2) domains and specific phosphotyrosine residues on the activated receptor (Pawson 1995).”
Signaling—2000 and Beyond (2000, background): “For example, the PHDs of the PDK1 and Akt/(van der Geer and Pawson, 1995).”
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. (2000, background): “Ligand binding induces dimerization of the EGFR and its autophosphorylation on several tyrosine residues in the intracellular domain, creating a series of high-affinity binding sites for various transducing molecules that are involved in transmitting the mitogenic signaling through theras/raf/mitoge”