Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus

By J. Cinatl, B. Morgenstern, G. Bauer, P. Chandra, Holger F. Rabenau, H. Doerr. The Lancet, 2003

1,087 citations recorded by the source corpus.

Summary The outbreak of SARS warrants the search for antiviral compounds to treat the disease. At present, no specific treatment has been identified for SARS-associated coronavirus infection. We assessed the antiviral potential of ribavirin, 6-azauridine, pyrazofurin, mycophenolic acid, and glycyrrhizin against two clinical isolates of coronavirus (FFM-1 and FFM-2) from patients with SARS admitted to the clinical centre of Frankfurt University, Germany. Of all the compounds, glycyrrhizin was the most active in inhibiting replication of the SARS-associated virus. Our findings suggest that glycyrrhizin should be assessed for treatment of SARS.

Subfields: Immunology, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/1e3a472b0d7b6ab43e6aa89fae227570288bd398

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Sajid Maqsood
2. Prabjeet Singh

In Molecular Biology

1. E. Keyaerts
2. L. Vijgen
3. Piet Maes
4. P. Szpak

Citations in the corpus

• Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review (2018, background): “Glycyrrhizin affects the cellular signalling pathways such as protein kinase C, casein kinase II, and transcription factors, namely, activator protein 1 and nuclear factor κB (Cinatl et al., 2003).”
• Emerging role of immunostimulants in combating the disease outbreak in aquaculture (2011, background): “components such as polysaccharides, alkaloids and/or flavonoids (Cinatl et al. 2003).”
• In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine (2004, background): “Since the epidemic, a lot of effort has been put into antiviral research to find compounds effective against SARS-CoV. Glycyrrhizin (an active component of liquorice roots), niclosamide (an antihelminthic drug), nelfinavir (a human immunodeficiency deficiency virus (HIV) protease inhibitor), and SNA”
• Severe Acute Respiratory Syndrome Coronavirus as an Agent of Emerging and Reemerging Infection (2007, background): “Protease inhibitors (especially nelfinavir) (386, 392), glycyrrhizin (77), baicalin (50), reserpine (381), aescin (381), valinomycin (381), niclosamide (380), aurintricarboxylic acid (129), mizoribine (293), indomethacin (4), chloroquine (174), and many herbal formulations, have also been found to p”