The immunology and immunopathology of COVID-19

By Miriam Merad, C. Blish, F. Sallusto, A. Iwasaki. Science, 2022

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Considerable research effort has been made worldwide to decipher the immune response triggered upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, identify the drivers of severe and fatal COVID-19, and understand what leads to the prolongation of symptoms after disease resolution. We review the results of almost 2 years of COVID-19 immunology research and discuss definitive findings and remaining questions regarding our understanding of COVID-19 pathophysiology. We discuss emerging understanding of differences in immune responses seen in those with and without Long Covid syndrome, also known as post-acute sequelae of SARS-CoV-2. We hope that the knowledge gained from this COVID-19 research will be applied in studies of inflammatory processes involved in critical and chronic illnesses, which remain a major unmet need. Description

Subfields: Infectious Diseases, Neurology

View Paper: https://www.semanticscholar.org/paper/1e2a730adfd20be5ac14890e2fc15f2a1ba622c3