The Future of Peptide‐based Drugs
By D. Craik, D. Fairlie, S. Liras, David A. Price. Chemical Biology and Drug Design, 2013
1,713 citations recorded by the source corpus.
Subfields: Molecular Biology, Organic Chemistry
View Paper: https://www.semanticscholar.org/paper/1e24cf86b9ce43fd08e55d9e6e09e513eaefeea4
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In Molecular Biology
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- Geoffrey D. Miller
In Organic Chemistry
Citations in the corpus
- 1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview (2019, background): “1,2,3-Triazole-linked peptide type compounds Peptide-like derivatives are not orally bioavailable; however, protein therapy tends to exhibit specificity against its targets because it interacts with a greater number of substances, but this occurs at the expense of low bio-availability and metabolic ”
- Basics and recent advances in peptide and protein drug delivery (2013, positive): “This cyclic peptide is resistant to proteolytic degradation and also has higher than expected absorption after oral administration [1].”
- Docking small peptides remains a great challenge: an assessment using AutoDock Vina (2015, background): “In addition to these functions of naturally occurring peptides, novel uses are created by means of biotechnological and pharmaceutical peptide optimization approaches [8, 9], or even de novo design [1012].”
- CancerPPD: a database of anticancer peptides and proteins (2014, background): “Since then peptides have not been very popular as drug candidates but it has only been in the recent past that the pharmaceutical industries have shown an interest in therapeutic peptides and made a heavy investment in the peptide-based drugs (3,36).”
- HPEPDOCK: a web server for blind peptide–protein docking based on a hierarchical algorithm (2018, background): “Therefore, determining the structure of protein–peptide complexes involved in these interactions is crucial for understanding the molecular mechanism and thus modulating the protein–protein interactions for therapeutic purpose (3,4).”
- Information-Driven, Ensemble Flexible Peptide Docking Using HADDOCK. (2017, background): “Peptides are receiving an increasing level of attention from the wider biological and pharmaceutical communities owing to an incre ase in the number of peptide-based drugs and therapeutics entering the market [1, 2].”
- Therapeutic peptides: current applications and future directions (2022, background): “ACE inhibition, ACE2 and angiotensin-(1-7) axis in kidney and cardiac inflammation and fibrosis.”