An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs).

By Vardhman K. Rakyan, Thomas A. Down, N. Thorne, Paul Flicek, Eugene Kulesha, Stefan Gräf, E. Tomazou, L. Bäckdahl, Nathan Johnson, M. Herberth and 10 more. 2008

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Ensembl 2009 (2008, methodology): “We have also recently participated in the creation of a genome-wide DNA methylation resource that has been incorporated into Ensembl (33,34).”
High-resolution genome-wide DNA methylation maps of mouse primary female dermal fibroblasts and keratinocytes (2014, neutral): “A major event during developmental differentiation in mammals is the demethylation of regions of DNA to produce TS-HMRs that may function to activate expression of nearby tissue-specific genes [14,15,18,25-28].”
Dynamic DNA methylation across diverse human cell lines and tissues (2013, result): “These data support previous observations that there is a large number of tissuespecific differentially methylated regions (tDMRs) (Rakyan et al. 2008) and that primary cell lines can serve as models for understanding epigenetic tissue-specific gene regulation at a large number of loci.”
SWAN: Subset-quantile Within Array Normalization for Illumina Infinium HumanMethylation450 BeadChips (2012, background): “Changes in DNA methylation are vital for normal development and differentiation [1], whilst aberrant methylation is involved in diseases such as diabetes, schizophrenia, multiple sclerosis and cancer [2-4].”