Plasma cell differentiation requires the transcription factor XBP-1

By A. Reimold, N. Iwakoshi, J. Manis, P. Vallabhajosyula, E. Szomolanyi-Tsuda, E. Gravallese, D. Friend, M. Grusby, F. Alt, Laurie H. Glimcher. Nature, 2001

1,354 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/1dfc4311305d843d95880fce616ef971fab1582f

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In Immunology

Citations in the corpus

The endoplasmic reticulum and the unfolded protein response. (2007, background): “Antigenic stimulation of mature B lymphocytes activates the UPR and signaling through IRE1-mediated XBP1 mRNA splicing is required to drive B lymphocyte differentiation into plasma cells [29,36-38].”
Orchestrating the unfolded protein response in health and disease. (2002, background): “5, the role of XBP1 in B and T cell development had to be studied in immunoincompetent RAG1–/– mice reconstituted with XBP1–/– embryonic stem cells (73).”
Endoplasmic reticulum stress signaling in disease. (2006, background): “XBP-1 was also shown to be essential for normal plasma cell differentiation (156, 157, 204).”
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers (2013, background): “XBP1 encodes a basic-region leucine zipper (bZIP) transcription factor of the CREB-ATF family that governs plasma cell differentiation (Reimold et al., 2001).”
IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response. (2002, background): “Interestingly, XBP1 mRNA is increased by anti-CD40 antibody or LPS treatment, suggesting that the UPR and the signaling pathway for plasma cell differentiation cooperate in the induction and splicing of XBP1 mRNA (Reimold et al. 2001).”
Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer (2017, neutral): “IRE1α–XBP1 signaling is required for the optimal differentiation of plasma cells, some dendritic cell populations and eosinophils in cancer-free hosts (Bettigole et al., 2015; Iwakoshi et al., 2007; Reimold et al., 2001).”
From acute ER stress to physiological roles of the Unfolded Protein Response (2006, background): “and xbp1 / B cells fail to differentiate into antibodysecreting plasma cells in vivo.(58) XBP1 splicing correlates with plasma cell differentiation, and ectopic expression of the”