Microbial tryptophan catabolites in health and disease
By H. Roager, T. R. Licht. Nature Communications, 2018
1,840 citations recorded by the source corpus.
Accumulating evidence implicates metabolites produced by gut microbes as crucial mediators of diet-induced host-microbial cross-talk. Here, we review emerging data suggesting that microbial tryptophan catabolites resulting from proteolysis are influencing host health. These metabolites are suggested to activate the immune system through binding to the aryl hydrocarbon receptor (AHR), enhance the intestinal epithelial barrier, stimulate gastrointestinal motility, as well as secretion of gut hormones, exert anti-inflammatory, anti-oxidative or toxic effects in systemic circulation, and putatively modulate gut microbial composition. Tryptophan catabolites thus affect various physiological processes and may contribute to intestinal and systemic homeostasis in health and disease. Gut microbial metabolites are known to impact many physiological processes of the host and play a critical role in immune-homeostasis. Here the authors review our current understanding and appreciation of the importance of microbially derived tryptophan catabolites during both health and disease.
Subfields: Biological Psychiatry, Molecular Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/1d6bd51d6ef5812aa0cb800ce96555278cfc338e
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Citations in the corpus
- Tryptophan Metabolism: A Link Between the Gut Microbiota and Brain. (2019, background): “Probiotics, such as bacteria belonging to the genera Lactobacillus and Bifidobacterium, are reported to exert beneficial effects on the tryptophan metabolism (22).”
- Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites (2020, background): “IPA is a specific metabolite whose production completely depends on tryptophan metabolism by the gut microbiota 18 and characterised as being anti-inflammatory and protective of intestinal barrier integrity.”