Can medial temporal lobe regions distinguish true from false? An event-related functional MRI study of veridical and illusory recognition memory
By Roberto Cabeza, S. Rao, Anthony D. Wagner, A. R. Mayer, Daniel L. Schacter. 2001
356 citations recorded by the source corpus.
To investigate the types of memory traces recovered by the medial temporal lobe (MTL), neural activity during veridical and illusory recognition was measured with the use of functional MRI (fMRI). Twelve healthy young adults watched a videotape segment in which two speakers alternatively presented lists of associated words, and then the subjects performed a recognition test including words presented in the study lists (True items), new words closely related to studied words (False items), and new unrelated words (New items). The main finding was a dissociation between two MTL regions: whereas the hippocampus was similarly activated for True and False items, suggesting the recovery of semantic information, the parahippocampal gyrus was more activated for True than for False items, suggesting the recovery of perceptual information. The study also yielded a dissociation between two prefrontal cortex (PFC) regions: whereas bilateral dorsolateral PFC was more activated for True and False items than for New items, possibly reflecting monitoring of retrieved information, left ventrolateral PFC was more activated for New than for True and False items, possibly reflecting semantic processing. Precuneus and lateral parietal regions were more activated for True and False than for New items. Orbitofrontal cortex and cerebellar regions were more activated for False than for True items. In conclusion, the results suggest that activity in anterior MTL regions does not distinguish True from False, whereas activity in posterior MTL regions does.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
- Florin Dolcos
- Roberto Cabeza
- Lars Nyberg
- Reiko Graham
- Cheryl L. Grady
- Randy L. Buckner
- Peter Fransson
- Arne Dietrich
Citations in the corpus
- The cognitive neuroscience of constructive memory: remembering the past and imagining the future (2007, unknown): “…and AD patients, these studies have revealed significant and comparable levels of activation in the MTL, including the hippocampus, during both true and false recognition of related lures (e.g. Schacter et al. 1996b; Cabeza et al. 2001; for more detailed review, see Schacter & Slotnick 2004).”
- Distinct prefrontal cortex activity associated with item memory and source memory for visual shapes. (2003, background): “fMRI evaluation of somatotopic representation in human primary [5] R.”
- Similarities and Differences in the Neural Correlates of Episodic Memory Retrieval and Working Memory (2002, methodology): “In ER studies, dorsolateral PFC activity has been attributed to the monitoring of retrieved information (Fletcher et al., 1998; Henson et al., 1999; Cabeza et al., 2001), and in WM studies, to the monitoring and manipulation of information within WM (e.g., Owen et al., 1996; D'Esposito et al.,…”