Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs.

By R. Krishna, L. Mayer. European Journal of Pharmaceutical Sciences, 2000

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Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come (2016, background): “SLNs containing cholesteryl butyrate and DOX demonstrated higher cytotoxicity than their conventional drug formulations, showing lower IC50 values (Serpe et al., 2004).”
Molecular mechanisms of drug resistance (2005, background): “These proteins can actively transport drugs out of cells and particularly target natural hydrophobic drugs such as taxanes, anthracyclines, and vinca alkaloids [9,10].”
Alkaloid tolerance in Manduca sexta and phylogenetically related sphingids (Lepidoptera: Sphingidae) (2002, background): “From other animals and humans it is known that ABC transporters and mdr proteins are inducible and important for the elimination of xenobiotics (Fromm 2000; LeBlanc 1994; Krishna and Mayer 2000; Smital & Kurelec 1998).”
Nanotechnology: Intelligent Design to Treat Complex Disease (2006, background): “efflux system, responsible for the multidrug resistance (MDR) or themultidrug-resistance-associated protein (20,21).”