Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer’s type in an elderly Arab population in Wadi Ara, Israel

By A. Bowirrat, Jing Cui, K. Waraska, R. Friedland, M. Oscar-Berman, L. Farrer, A. Korczyn, C. Baldwin. Neuropsychiatric Disease and Treatment, 2005

652 citations recorded by the source corpus.

The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer’s disease (AD). This study investigated whether the ACE gene insertion–deletion (ID) polymorphism is associated with risk of developing dementia of Alzheimer’s type (DAT) in an Arab–Israeli community, a unique genetic isolate where there is a high prevalence of DAT. In contrast to several other studies, we found no evidence of an association between this polymorphism and either DAT or age-related cognitive decline (ARCD).

Subfields: Cardiology and Cardiovascular Medicine, Pharmacology

View Paper: https://www.semanticscholar.org/paper/1cce9dcd90917ccd10704c05823667d8a85dc770

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Citations in the corpus

On the structure of Selmer groups over -adic Lie extensions (2002, result): “If E has ordinary reduction at v|p, then by a result of Serre (see [Se2] IV-43), we have dim(Gv) = 3 (see [CH] Lemma 5.1).”