Acute-phase proteins: As diagnostic tool
By S. Jain, Vidhi Gautam, S. Naseem. Journal of Pharmacy and Bioallied Sciences, 2011
639 citations recorded by the source corpus.
The varied reactions of the host to infection, inflammation, or trauma are collectively known as the acute-phase response and encompass a wide range of pathophysiological responses such as pyrexia, leukocytosis, hormone alterations, and muscle protein depletion combining to minimize tissue damage while enhancing the repair process. The mechanism for stimulation of hepatic production of acute-phase proteins is by proinflammatory cytokines. The functions of positive acute-phase proteins (APP) are regarded as important in optimization and trapping of microorganism and their products, in activating the complement system, in binding cellular remnants like nuclear fractions, in neutralizing enzymes, scavenging free hemoglobin and radicals, and in modulating the host’s immune response. APP can be used as diagnostic tool in many diseases like bovine respiratory syncytial virus, prostate cancer, bronchopneumonia, multiple myeloma, mastitis, Streptococcus suis infection, starvation, or lymphatic neoplasia. Thus, acute-phase proteins may provide an alternative means of monitoring animal health.
Subfields: Animal Science and Zoology, Infectious Diseases, Small Animals
View Paper: https://www.semanticscholar.org/paper/1ccb83f56797de4346e77f78437479478cd020ef
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In Animal Science and Zoology
In Small Animals
Citations in the corpus
- Towards Heat Stress Management in Small Ruminants – A Review (2017, background): “The maximum concentration is usually reached within 24–48 hours after stimulation and declines with recovery from the infection (Jain et al., 2011).”