Determination of 50% endpoint titer using a simple formula.

By M. Ramakrishnan. World Journal of Virology, 2016

712 citations recorded by the source corpus.

Two commonly used methods for calculating 50% endpoint using serial dilutions are Spearman-Karber method and Reed and Muench method. To understand/apply the above formulas, moderate statistical/mathematical skills are necessary. In this paper, a simple formula/method for calculating 50% endpoints has been proposed. The formula yields essentially similar results as those of the Spearman-Karber method. The formula has been rigorously evaluated with several samples.

Subfields: Statistics and Probability

View Paper: https://www.semanticscholar.org/paper/1c876c0988aae4587023646e5bc7b517207784f0

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1. Hui Wang
2. Yuntao Zhang
3. Wenling Wang
4. Baoying Huang
5. Wei Deng
6. Yaru Quan
7. L. Bao
8. Guizhen Wu

Citations in the corpus

• Development of an Inactivated Vaccine Candidate, BBIBP-CorV, with Potent Protection against SARS-CoV-2 (2020, positive): “The virus titer was calculated by the method of Karber (Ramakrishnan, 2016).”
• Predicting infectious SARS-CoV-2 from diagnostic samples (2020, methodology): “TCID50 and TCID50/mL were calculated using the Reed and Muench method previously described [6]”