Acute infection and macrophage subversion by Mycobacterium tuberculosis require a specialized secretion system

By S. Stanley, S. Raghavan, W. W. Hwang, J. Cox. Proceedings of the National Academy of Sciences of the United States of America, 2003

603 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/1c6b66da9c7842e1708736a365cb15cca5604163

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Infectious Diseases

1. B. B. Finlay
2. L. Ramakrishnan
3. G. McFadden

In Physiology

1. J. Cox
2. B. B. Finlay
3. R. Watson
4. P. Manzanillo

Citations in the corpus

• Type VII secretion — mycobacteria show the way (2007, background): “However, recent studies have provided evidence that there is an alternative protein-secretion system in Gram-positive bacteri”
• Proteomics of Protein Secretion by Bacillus subtilis: Separating the “Secrets” of the Secretome (2004, background): “tuberculosis are secreted in a signal peptide- and Sec-dependent manner, most proteins are released into the medium by cell lysis or via specific Sec-independent export mechanisms, such as the Snm system (117, 123).”
• Anti-immunology: evasion of the host immune system by bacterial and viral pathogens. (2006, background): “Similarly, Mycobacterium tuberculosis has a specialized secretion system that is needed to deliver major T cell antigens (ESAT-6 and CFP-10) and presumably other proteins that are needed for bacterial replication inside macrophages and virulence (Stanley et al., 2003).”
• M. tuberculosis and M. leprae translocate from the phagolysosome to the cytosol in myeloid cells. (2007, background): “The ESX-1 region has an important role in the virulence of M. tuberculosis (Lewis et al., 2003; Hsu et al., 2003; Stanley et al., 2003).”
• Non-classical protein secretion in bacteria (2005, background): “All three proteins may constitute parts of the translocation machinery of the Snm system [14].”
• The Role of the Granuloma in Expansion and Dissemination of Early Tuberculous Infection (2009, background): “RD1 has been thought to promote mycobacterial infection by dampening the innate immune response in order to evade its bactericidal mechanisms (Pathak et al., 2007; Stanley et al., 2003), although more recent evidence suggests that RD1 enhances inflammation (Koo et al.”
• Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway (2012, positive): “tuberculosis infection (Stanley et al., 2003) but is also required for selective targeting of salmonella to autophagy (Wild et al.”