Synaptic Tagging During Memory Allocation

By Thomas Rogerson, Denise J. Cai, Adam Frank, Yoshitake Sano, Justin L. Shobe, M. Aranda, Alcino J. Silva. 2014

255 citations recorded by the source corpus.

There is now compelling evidence that the allocation of memory to specific neurons (neuronal allocation) and synapses (synaptic allocation) in a neurocircuit is not random and that instead specific mechanisms, such as increases in neuronal excitability and synaptic tagging and capture, determine the exact sites where memories are stored. We propose an integrated view of these processes, such that neuronal allocation, synaptic tagging and capture, spine clustering and metaplasticity reflect related aspects of memory allocation mechanisms. Importantly, the properties of these mechanisms suggest a set of rules that profoundly affect how memories are stored and recalled.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Structural Components of Synaptic Plasticity and Memory Consolidation. (2015, background): “learning and memory (reviewed in Yuste and Bonhoeffer 2001; Alvarez and Sabatini 2007; Bourne and Harris, 2007, 2008; Rogerson et al. 2014).”
Memory engrams: Recalling the past and imagining the future (2020, background): “Optogenetic or chemogenetic (56, 57) artificial reactivation of tagged or allocated engram cells across several brain regions similarly induced memory expression for a variety of tasks without external retrieval cues (27, 38, 58-64).”