An estimated 5% of new protein structures solved today represent a new Pfam family

By Jaina Mistry, Edda Kloppmann, Burkhard Rost, Marco Punta. 2013

13 citations recorded by the source corpus.

This study uses the Pfam database to show that the sequence redundancy of protein structures deposited in the PDB is increasing. The possible reasons behind this trend are discussed.

Subfields: Materials Chemistry, Molecular Biology

Citations in the corpus

• Better prediction of functional effects for sequence variants (2015, neutral): “About 10-20% of all proteins in newly sequenced organisms continue not to map anywhere else in today’s databases [33,34,55]; for those 10-20% of proteins, SNAP2noali appears to be the best method available to predict the effect of mutations.”