The medicinal chemist's toolbox: an analysis of reactions used in the pursuit of drug candidates.

By Stephen D. Roughley, A. Jordan. 2011

2,042 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System Targets (2015, background): “Useful perspectives on how medicinal chemists approach drug design would include the reactions commonly in their toolboxes (49), and how they exploit molecular interactions (14).”
Rethinking drug design in the artificial intelligence era (2019, background): “The choice of reactions for automation should primarily focus on the ones frequently employed by medicinal chemists 135,136 , so the chemist is free to perform the more challenging synthetic steps and conceive new chemical reactions 137,138 .”
Rethinking amide bond synthesis (2011, neutral): “GLP-1 (22-36) Interleukin-8 (35-72) I n t e r l e u k i n 8 ( 1 3 3 )RNase A (11 –124) G L P 1 ( 2 2 3 6 ) I n t e r l e u k i n 8 ( 3 5 7 2 ) Interleukin-8 (1-33) RNase A (110–111)”