Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

By Lena F. Burbulla, Pingping Song, Joseph R. Mazzulli, Enrico Zampese, Y. Wong, Sohee Jeon, David P. Santos, Judith Blanz, C. Obermaier, Chelsee Strojny and 6 more. Science, 2017

766 citations recorded by the source corpus.

Subfields: Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/1b7cf43cef1a0b083cd231610d6b16c5236dcf8a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Neurology

1. L. Volpicelli-Daley
2. D. Bailey
3. Maria Luisa Fiorello
4. J. Cobley

In Physiology

1. D. Bailey
2. Maria Luisa Fiorello
3. J. Cobley

Citations in the corpus

• 13 reasons why the brain is susceptible to oxidative stress (2018, background): “In PD, dopamine oxidation [160] drives mitochon-”
• Alpha-synuclein in Parkinson’s disease and other synucleinopathies: from overt neurodegeneration back to early synaptic dysfunction (2023, background): “In particular, increased mitochondrial oxidative stress in fibroblast-derived induced pluripotent stem cells, differentiated into human nigral DA neurons, triggers a DA-dependent toxic cascade, leading to oxidized DA accumulation and reduction in glucocerebrosidase enzymatic activity, lysosomal dysf”