Influence of tumour micro-environment heterogeneity on therapeutic response
By M. Junttila, F. Sauvage. Nature, 2013
2,517 citations recorded by the source corpus.
Subfields: Biomedical Engineering, Modeling and Simulation, Oncology
View Paper: https://www.semanticscholar.org/paper/1b78f56e469c1fa385fa9b05ef5104bb239ec1f2
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In Biomedical Engineering
In Modeling and Simulation
In Oncology
- J. Joyce
- D. Quail
- J. Seoane
- Christopher S. Hackett
- Garry P. Nolan
- G. J. Yoshida
- Eric C. Holland
- G. Gores
Citations in the corpus
- The tumor microenvironment underlies acquired resistance to CSF1R inhibition in gliomas (2016, background): “99125A(2) and06-107], as previously described (8, 60).”
- Engineering strategies to overcome the current roadblocks in CAR T cell therapy (2019, background): “The complicated structure and cellular milieu of solid tumours influences both tumour biology and response to therapy 130 .”
- Spherical Cancer Models in Tumor Biology (2015, background): “More sophisticated 3D systems combining cancer and stromal cells could emphasize the importance of heterotypic cross talk [9,10].”
- Coordinated Cellular Neighborhoods Orchestrate Antitumoral Immunity at the Colorectal Cancer Invasive Front (2019, background): “…efforts have highlighted how interactions between distinct components of the immune tumor microenvironment (iTME) play crucial roles in dictating cancer development, progression, rejection, and therapeutic response (Junttila and de Sauvage, 2013; Schreiber et al., 2011; Williams et al., 2016).”
- SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics (2019, background): “In the particular case of tumors, cancer cells can reprogram their micro-environment through secreted factors, turning neutral or anti-tumor cells into tumor supportive elements (7,8).”
- Metabolic reprogramming: the emerging concept and associated therapeutic strategies (2015, background): “Stromal cells such as neurons, vascular endothelial cells, fibroblasts, and macrophages in cancer tissue drive chemotherapy resistance [1] as well as tumor survival and progression [2, 3].”
- Revisiting the hallmarks of cancer. (2017, neutral): “A final point to be made is our grown appreciation for “cancer-organ”, rather than “cancercellular”, therapeutic response [186].”