Solubility and partitioning I: Solubility of nonelectrolytes in water.

By S. Yalkowsky, S. Valvani. 1980

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In silico prediction of aqueous solubility (2006, background): “Yalkowsky and Valvani [18] have given the theoretical derivation of the general form of Equation 5.”
The influence of lipophilicity in drug discovery and design (2012, background): “The general solubility equation is described in Figure 2 [49,50].”
Contribution of solid-state properties to the aqueous solubility of drugs. (2006, background): “Of particular interest in this respect is the general solubility equation (GSE) developed by Yalkowsky and co-workers (Jain and Yalkowsky, 2001; Yalkowsky and Valvani, 1980), which is based on the log P together with the melting point (Tm).”
Lipophilicity in drug discovery (2010, background): “Hence, Yalkowsky et al. have proposed the empirically derivedGeneral Solubility Equation [16] that describes the solubility of a compound as a function of logP andmelting point, in which themelting point describes the lattice energy that is lost on dissolution.”
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules (2017, unknown): “Both differ from the seminal general solubility equation 38 since they avoid the melting point parameter; the latter being challenging to predict.”