The combinatorial synthesis of bicyclic privileged structures or privileged substructures.

By Douglas A. Horton, G. Bourne, M. Smythe. Chemical Reviews, 2003

2,531 citations recorded by the source corpus.

Subfields: Molecular Biology, Organic Chemistry

View Paper: https://www.semanticscholar.org/paper/1b06c289f107d4e832da8fd1fc39a7a33002c25f

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In Molecular Biology

1. Frederick P. Roth
2. Sun-Yuan Kung
3. Patrik D'haeseleer
4. Amit Singer

Citations in the corpus

• Solar Synthesis: Prospects in Visible Light Photocatalysis (2014, neutral): “Moreover, the ability to rapidly modify the environment around an amine holds particular promise in the discovery of structurally complex new bioactive compounds, because nitrogen-containing functional groups are very often important in the binding of a small molecule to a biological target (47).”
• Chemical substructures that enrich for biological activity (2008, background): “Our analysis also revealed ‘underprivileged’ substructures and ‘conditional privilege’—rules relating combinations of substructure to bioactivity.”