A Splice Code for trans-Synaptic Cell Adhesion Mediated by Binding of Neuroligin 1 to α- and β-Neurexins

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Neuroligins determine synapse maturation and function. (2006, neutral): “…family of four (in rodents) or five (in higher primates and humans) postsynaptic cell adhesion proteins that interact with presynaptic a- and b-neurexins (NXs) (Boucard et al., 2005; Ichtchenko et al., 1995; Song et al., 1999; Varoqueaux et al., 2004) via a large extracellular esterase-like domain.”
Activity-dependent validation of excitatory versus inhibitory synapses by neuroligin-1 versus neuroligin-2. (2007, positive): “(F and G) Representative traces (F) and summary graphs (G) of electrophysiological recordings of AMPAR-dependent EPSCs in neurons transfected with control vector or vectors expressing all four alternative splice variants of NL1 (Boucard et al., 2005).”
Resolving RNA complexity to decipher regulatory rules governing biological networks (2010, neutral): “This suggests that a 'splice code' might underlie trans-synaptic cell adhesio”
Neurexin-neuroligin signaling in synapse development. (2007, background): “[43 ] strongly suggest that only LNS6 ofa-neurexins mediates binding to B neuroligin 1.”