Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle

By K. Roch, Yingyao Zhou, P. Blair, M. Grainger, J. K. Moch, J. Haynes, P. D. L. Vega, A. Holder, S. Batalov, D. Carucci and 1 more. Science, 2003

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Antimalarial drug discovery: efficacy models for compound screening (2004, background): “The former offer the opportunity to survey transcription across the plasmodial life cycl”
A Systematic Map of Genetic Variation in Plasmodium falciparum (2006, positive): “falciparum control sequences on the array, also as previously described [14].”
Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility (2010, neutral): “References: 1 [4]; 2 [52]; 3 [17]; 4 [18]; 5 [71]; 6 [72]; 7 [73]; 8 [74]; 9 [12]; 10 [75]; 11 [10]; 12 [13]; 13 [8]; 14 [16]; 15 [14]; 16 [41]; 17 [76]; 18 [15].”
Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination (2011, background): “proteomics have identified 250 to 300 sexual stage-specific genes, 75% of which were hypothetical at the time of identification (149, 155, 239, 247).”
The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle (2016, background): “P38 is reported to be expressed in schizonts, sexual stages and sporozoites by several transcriptomic and proteomic studies (Bozdech et al., 2003; Le Roch et al., 2003; Gilson et al., 2006; Silvestrini et al., 2010; Lindner et al., 2013).”