Cyclic Nucleotide Monophosphates and Their Cyclases in Plant Signaling

By Chris Gehring, I. Turek. 2017

93 citations recorded by the source corpus.

The cyclic nucleotide monophosphates (cNMPs), and notably 3′,5′-cyclic guanosine monophosphate (cGMP) and 3′,5′-cyclic adenosine monophosphate (cAMP) are now accepted as key signaling molecules in many processes in plants including growth and differentiation, photosynthesis, and biotic and abiotic defense. At the single molecule level, we are now beginning to understand how cNMPs modify specific target molecules such as cyclic nucleotide-gated channels, while at the systems level, a recent study of the Arabidopsis cNMP interactome has identified novel target molecules with specific cNMP-binding domains. A major advance came with the discovery and characterization of a steadily increasing number of guanylate cyclases (GCs) and adenylate cyclases (ACs). Several of the GCs are receptor kinases and include the brassinosteroid receptor, the phytosulfokine receptor, the Pep receptor, the plant natriuretic peptide receptor as well as a nitric oxide sensor. We foresee that in the near future many more molecular mechanisms and biological roles of GCs and ACs and their catalytic products will be discovered and further establish cNMPs as a key component of plant responses to the environment.

Subfields: Plant Science

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In Plant Science

1. Lars-Oliver Essen
2. Neda Farmani
3. Javier Serranía
4. L. Werel
5. E. Krol
6. Anke Becker

Citations in the corpus

• Structural Basis of Dual Specificity of Sinorhizobium meliloti Clr, a cAMP and cGMP Receptor Protein (2023, background): “A role for cGMP in plant signal transductions related to development, stress response, ion homeostasis, and hormone function has been demonstrated, and long-distance cGMP signaling was suggested (77, 78).”