Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part II: the aging heart in health: links to heart disease.

By E. Lakatta, Daniel Levy. Circulation, 2003

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An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations. (2007, background): “While it is unclear whether longerterm antioxidant treatments might prove effective in dealing with aging and conditions, such as vascular aging, provocative results from acute-treatment studies suggest that the vasculature should be viewed as a key target for therapeutic intervention (133, 180, 239”
Growth Differentiation Factor 11 is a Circulating Factor that Reverses Age-Related Cardiac Hypertrophy (2013, neutral): “Left ventricular hypertrophy is an important feature of cardiac aging, contributing to diastolic dysfunction and heart failure with preserved systolic function (Lakatta and Levy, 2003).”
Aging-associated cardiovascular changes and their relationship to heart failure (2012, background): “dysfunction, increased afterload, and HF with preserved ejection fraction (HFpEF).(6,7) These are described individually in the Cardiac structural and Central Arterial structural sections later in this article.”