Isolation and identification of an endophytic strain of Fusarium oxysporum producing podophyllotoxin from Juniperus recurva

By A. Kour, A. S. Shawl, S. Rehman, P. Sultan, P. Qazi, Pankaj Suden, R. Khajuria, V. Verma. 2008

233 citations recorded by the source corpus.

Subfields: Ecology, Evolution, Behavior and Systematics, Molecular Biology, Pharmacology

View Paper: https://www.semanticscholar.org/paper/1a8e72202ed5221649f0acfda2b23ddebe172f61

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In Ecology, Evolution, Behavior and Systematics

1. A. Aly
2. A. Debbab
3. J. Kjer
4. P. Proksch
5. S. Kusari
6. M. Spiteller

In Molecular Biology

1. A. Aly
2. A. Debbab
3. P. Proksch
4. S. Kusari
5. M. Spiteller

In Pharmacology

1. P. Proksch
2. A. Debbab
3. A. Aly
4. S. Kusari
5. M. Spiteller
6. S. Mattila
7. M. Tejesvi
8. A. Pirttilä

Citations in the corpus

• Bioactivity and genetic diversity of endophytic fungi in Rhododendron tomentosum Harmaja (2011, background): “Recently, podophyllotoxin, a precursor for production of clinically used anticancer drugs etoposide and teniposide, was also reported as a product of endophytic Fusarium oxysporum of Juniperus recurva (Kour et al. 2008).”
• Fungal endophytes: unique plant inhabitants with great promises (2011, background): “oxysporum endophytic in the medicinal plant Juniperus recurva, which produces podophyllotoxin as well, with a yield of 28 μg/g dry mass (Kour et al. 2008).”
• Metabolomics of Endophytic Fungi Producing Associated Plant Secondary Metabolites: Progress, Challenges and Opportunities (2012, background): “, 2006), and Fusarium oxysporum isolated from Juniperus recurva (Kour et al., 2008).”
• Endophytic fungi for producing bioactive compounds originally from their host plants (2010, unknown): “Podophyllotoxin (PDT), a well-known aryltetralin lignan with potent anticancer, antiviral, antioxidant, antibacterial, immunostimulation and anti-rheumatic properties, mainly occurs in genera of Diphylleia, Dysosma, Sabina (also called Juniperus), and Sinopodophyllum (also called Podophyllum) [45-52”
• Endophytic Fungi: Natural Products, Enzymes and Biotransformation Reactions (2009, methodology): “Additionally, endophytes might acquire the ability to biosynthesize some phytochemicals also produced by the host plant [36,37].”
• Fungal endophytes from higher plants: a prolific source of phytochemicals and other bioactive natural products (2010, background): “…herbal compounds in endophytes is by no means restricted to paclitaxel but extends also to further pharmacologically important natural products such as camptothecin (2) (Puri et al. 2005; Amna et al. 2006), podophyllotoxin (3) (Puri et al. 2006; Eyberger et al. 2006; Kour et al. 2008) and others.”
• SCREENING OF ANTIMICROBIAL AND ANTIOXIDANT SECONDARY METABOLITES FROM ENDOPHYTIC FUNGI ISOLATED FROM WHEAT (TRITICUM DURUM) (2013, background): “…potent anticancer, antiviral, antioxidant, antibacterial, immunostimulation, and anti-rheumatic properties, are obtained from endophytic fungus Alternaria sp. isolated from Sinopodophyllum, and endophytic fungus Fusarium oxysporum obtained from Sabina recurva (Gao et al. 2007; Kour et al. 2008).”