Triple dissociation of information processing in dorsal striatum, ventral striatum, and hippocampus on a learned spatial decision task
By M. V. Meer, Adam Johnson, Neil Schmitzer-Torbert, A. David Redish. 2010
240 citations recorded by the source corpus.
Summary Decision-making studies across different domains suggest that decisions can arise from multiple, parallel systems in the brain: a flexible system utilizing action-outcome expectancies, and a more rigid system based on situation-action associations. The hippocampus, ventral striatum and dorsal striatum make unique contributions to each system, but how information processing in each of these structures supports these systems is unknown. Recent work has shown covert representations of future paths in hippocampus, and of future rewards in ventral striatum. We developed new analyses in order to use a comparative methodology and apply the same analyses to all three structures. Covert representations of future paths and reward were both absent from the dorsal striatum. In contrast, dorsal striatum slowly developed situation representations that selectively represented action-rich parts of the task. This triple dissociation suggests that the different roles these structures play are due to differences in information processing mechanisms.
Subfields: Cognitive Neuroscience
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In Cognitive Neuroscience
- J. Gauthier
- Shantanu P. Jadhav
- Margaret F. Carr
- David W. Tank
- Loren M. Frank
- David J. Foster
- György Buzsáki
- Y. Dudai
Citations in the corpus
- Hippocampal replay in the awake state: a potential physiological substrate of memory consolidation and retrieval (2011, background): “, in which the replay of possible future trajectories is seen in a multiple-T maze tasks where animals must make memory-guided decision”
- A dedicated population for reward coding in the hippocampus (2018, result): “Because any cells encoding the goal would likely be a small population (Hollup et al., 2001; Dupret et al., 2010; Dombeck et al., 2010; van der Meer et al., 2010; Danielson et al., 2016), and because previous studies have reported low yield from electrode recordings in the subiculum (Sharp, 1997;…”
- Sequence Learning and the Role of the Hippocampus in Rodent Navigation (2012, unknown): “Recent evidence supports the notion that areas downstream of the hippocampus may act in accord with this conception of hippocampal place cell function, with the ventral striatum being the downstream critic [22,23 ] and the dorsal striatum being the downstream actor [24].”