Cortical Parvalbumin Interneurons and Cognitive Dysfunction in Schizophrenia
By D. Lewis, Allison A. Curley, J. Glausier, D. Volk. Trends in Neurosciences, 2011
1,065 citations recorded by the source corpus.
Deficits in cognitive control, a core disturbance of schizophrenia, appear to emerge from impaired prefrontal gamma oscillations. Cortical gamma oscillations require strong inhibitory inputs to pyramidal neurons from the parvalbumin basket cell (PVBC) class of GABAergic neurons. Recent findings indicate that schizophrenia is associated with multiple pre- and post-synaptic abnormalities in PVBCs, each of which weakens their inhibitory control of pyramidal cells. These findings suggest a new model of cortical dysfunction in schizophrenia in which PVBC inhibition is decreased to compensate for an upstream deficit in pyramidal cell excitation. This compensation is thought to re-balance cortical excitation and inhibition, but at a level insufficient to generate the gamma oscillation power required for high levels of cognitive control.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/19eedcf604b1dd7dba9d3cc13b0bd789d0664849
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
Citations in the corpus
- Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment (2023, result): “Post-mortem studies, in line with a model of cortical disinhibition, have found reductions in the enzymes GAD65 and GAD67, which are required for GABA synthesis, as well as reduced excitatory input to inhibitory neurons, and reduced interneuron numbers [212, 213].”