Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

By Melanie Fritsch, S. D. Günther, Robin Schwarzer, Marie‐Christine Albert, Fabian Schorn, J. Werthenbach, Lars M. Schiffmann, N. Stair, Hannah Stocks, J. Seeger and 4 more. Nature, 2019

943 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/19b512f5b396df8da9415341d92f76ccb4ec6617

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In Molecular Biology

1. Yaqiu Wang
2. T. Kanneganti

Citations in the corpus

• From pyroptosis, apoptosis and necroptosis to PANoptosis: A mechanistic compendium of programmed cell death pathways (2021, background): “Mice carrying an uncleavable RIPK1 (D325A) also undergo embryonic lethality due to abnormally abundant apoptotic and necroptotic cell death, resembling Casp8 (cid:1) / (cid:1) [109] and enzymatically inactive CASP8 (C362S or C362A) embryos [110,111].”
• Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes (2020, neutral): “In addition to its classical role in inducing apoptosis, caspase-8 plays a critical role in regulating inflammatory cell death pathways, including pyroptosis and necroptosis (Fritsch et al., 2019; Gurung et al., 2014; 2016; Kuriakose et al., 2016; Lukens et al., 2014; Malireddi et al., 2020; 2018; N”