Mesenchymal Stem Cell-Mediated Functional Tooth Regeneration in Swine

By W. Sonoyama, Yi Liu, D. Fang, T. Yamaza, B. Seo, Chunmei Zhang, He Liu, S. Gronthos, Cun-Yu Wang, S. Shi and 1 more. PLoS ONE, 2006

1,336 citations recorded by the source corpus.

Mesenchymal stem cell-mediated tissue regeneration is a promising approach for regenerative medicine for a wide range of applications. Here we report a new population of stem cells isolated from the root apical papilla of human teeth (SCAP, stem cells from apical papilla). Using a minipig model, we transplanted both human SCAP and periodontal ligament stem cells (PDLSCs) to generate a root/periodontal complex capable of supporting a porcelain crown, resulting in normal tooth function. This work integrates a stem cell-mediated tissue regeneration strategy, engineered materials for structure, and current dental crown technologies. This hybridized tissue engineering approach led to recovery of tooth strength and appearance.

Subfields: Genetics, Surgery, Urology

View Paper: https://www.semanticscholar.org/paper/198c448054f4416e0fcd7a6d5dda815dd90bce53

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. G. T. Huang
2. S. Shi
3. S. Gronthos
4. Rocky S. Tuan
5. A. Caplan

In Urology

1. S. Shi
2. G. T. Huang
3. S. Gronthos

Citations in the corpus

• Stem/Progenitor Cell–Mediated De Novo Regeneration of Dental Pulp with Newly Deposited Continuous Layer of Dentin in an In Vivo Model (2009, neutral): “8,9 Moreover, SCAP are cells from a developing tissue and are more robust than DPSCs in terms of population doubling capacity, proliferation rate, telomerase activity, and cell migration ability.”
• Mesenchymal Stem Cells Derived from Dental Tissues vs. Those from Other Sources: Their Biology and Role in Regenerative Medicine (2009, methodology): “…in various tissues and organs, including liver, spleen, and kidney, suggesting their potent differentiation plasticity (Kerkis et al., 2006). stem cells from Apical Papilla (scAP) Apical papilla refers to the soft tissue at the apices of developing permanent teeth (Sonoyama et al., 2006, 2008).”
• Importance of the pig as a human biomedical model (2021, positive): “Stem cells, isolated from the soft tissue attached to the immature teeth embedded in the gum, have been successfully used to form the root/periodontal complex of artificial tooth crowns in the minipig (54).”