Controlled production of monodisperse double emulsions by two-step droplet breakup in microfluidic devices.

By Shingo Okushima, Takasi Nisisako, T. Torii, T. Higuchi. Langmuir, 2004

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Double emulsion production in glass capillary microfluidic device: Parametric investigation of droplet generation behaviour (2015, background): “The most common microfluidic strategies for drop generation are flow focusing (Chen et al., 2009; Pannacci et al., 2008; Seo et al., 2007), T-junction (Nisisako et al., 2005; Okushima et al., 2004) and co-flowing (Cramer et al., 2004; Herrada et al., 2010; Perro et al., 2011).”
Production of uniform droplets using membrane, microchannel and microfluidic emulsification devices (2012, background): “Two T junctions in series with alternating surface wettabilities (e.g. an upstream hydrophilic junction followed by downstream hydrophobic junction) can produce multiple emulsions with a controlled number of inner drops (Okushima et al., 2004; Nisisako et al., 2005).”
Transition from squeezing to dripping in a microfluidic T-shaped junction (2008, positive): “Bioanalysis diagnostic assays Sia et al. (2004) handling and/or analysis of living cells He et al.”