Best Care at Lower Cost: The Path to Continuously Learning Health Care in America

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Caveats for the Use of Operational Electronic Health Record Data in Comparative Effectiveness Research (2013, positive): “This investment sets the foundation for a “learning” healthcare system that facilitates clinical research, quality improvement, and other data-driven efforts to improve health [5, 6].”
Dying in America: improving quality and honoring individual preferences near the end of life. (2015, background): “The urgency of undertaking this effort rests on the confluence of three major trends impelling change: the rising complexity and fragmentation of modern health care, unsustainable cost increases, and outcomes that do not reflect the system’s potential (IOM, 2013b).”
State of the art review: the data revolution in critical care (2015, background): “But 65 years after the first RCT was published, only 10–20% of medical decisions are based on RCT-supported evidence [11].”
Comparison of Variable Selection Methods for Clinical Predictive Modeling (2018, background): “…infrastructure takes hold in the healthcare environment, clinical researchers find themselves with a new set of opportunities and challenges, and top amongst these is making the best possible use of the large amounts of clinical data available to make new discoveries and improve patient care [1–3].”