Long-range LD can confound genome scans in admixed populations.

By Alkes L Price, M. Weale, Nick Patterson, S. Myers, A. Need, K. Shianna, D. Ge, J. Rotter, E. Torres, K. Taylor and 2 more. 2008

455 citations recorded by the source corpus.

Subfields: Genetics

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Citations in the corpus

Genome-wide association studies in ancestrally diverse populations: opportunities, methods, pitfalls, and recommendations. (2019, background): “2) and excluding regions of long-range LD (Price et al., 2008).”
Geographic variation and bias in polygenic scores of complex diseases and traits in Finland (2018, background): “05 or that resided in the major histology complex (chr 6: 25-34 Mb) (Price et al. 2008).”
Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci (2010, background): “We first excluded the 24 regions of long-range LD including the MHC identified in ref”
Insights about clonal hematopoiesis from 8,342 mosaic chromosomal alterations (2018, background): “The chr3, chr6, and chr8 regions have all been previously noted to harbor long-range LD [73], which suggested sample contamination [8] as the likely culprit: if a sample were contaminated with cells from another individual, then in regions of long-range LD (i.”
Genome-wide genetic data on ~500,000 UK Biobank participants (2017, methodology): “We computed the top 40 PCs using a set of 407,219 unrelated, high quality samples and 147,604 high quality markers pruned to minimise linkage disequilibrium (LD) [37].”
Functionally-informed fine-mapping and polygenic localization of complex trait heritability (2019, background): “We excluded the MHC region (chr6 25.5–33.5 M) and two other long-range LD regions (chr8 8–12 M, chr11 46–57 M) 62 from all analyses, following our observations that both FINEMAP and SuSiE tend to produce spurious results in these regions, finding many SNPs with PIP = 1 across many traits regardless…”
The Genetic Ancestry of African Americans, Latinos, and European Americans across the United States (2015, unknown): “27,63,65 If such regions were to drive artifacts of spurious ancestry, we would expect that segments of local ancestry would probably occur around these regions, rather than in a uniform distribution across the genome.”