Bile acid–microbiota cross-talk in gastrointestinal inflammation and carcinogenesis

By Wei Jia, G. Xie, Weiping Jia. Nature reviews: Gastroenterology & hepatology, 2017

1,648 citations recorded by the source corpus.

Emerging evidence points to a strong association between the gut microbiota and the risk, development and progression of gastrointestinal cancers such as colorectal cancer (CRC) and hepatocellular carcinoma (HCC). Bile acids, produced in the liver, are metabolized by enzymes derived from intestinal bacteria and are critically important for maintaining a healthy gut microbiota, balanced lipid and carbohydrate metabolism, insulin sensitivity and innate immunity. Given the complexity of bile acid signalling and the direct biochemical interactions between the gut microbiota and the host, a systems biology perspective is required to understand the liver–bile acid–microbiota axis and its role in gastrointestinal carcinogenesis to reverse the microbiota-mediated alterations in bile acid metabolism that occur in disease states. An examination of recent research progress in this area is urgently needed. In this Review, we discuss the mechanistic links between bile acids and gastrointestinal carcinogenesis in CRC and HCC, which involve two major bile acid-sensing receptors, farnesoid X receptor (FXR) and G protein-coupled bile acid receptor 1 (TGR5). We also highlight the strategies and cutting-edge technologies to target gut-microbiota-dependent alterations in bile acid metabolism in the context of cancer therapy.

Subfields: Oncology, Surgery

View Paper: https://www.semanticscholar.org/paper/18d994afef291e186220de1626bb319d34faffd0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Xiang Zhang
O. Coker
E. Chu
Kaili Fu
H. C. Lau
Yi-Xiang J. Wang
A. Chan
Hong Wei

Citations in the corpus

Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites (2020, background): “40 Therefore, the decreased Bifidobacterium and Bacteroides in the stool of HFHC-fed mice may account for the accumulated taurine-conjugated bile acids in HFHC-fed mice.”