Iterative approach to computational enzyme design

By H. Privett, G. Kiss, Toni M. Lee, R. Blomberg, R. Chica, L. Thomas, Donald Hilvert, K. Houk, Stephen L. Mayo. 2012

327 citations recorded by the source corpus.

Subfields: Materials Chemistry, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Materials Chemistry

1. I. Samish
2. Chun-chao Lo
3. Xiuwen Liu
4. Wei Wu
5. Jinfeng Zhang
6. Yang Chen
7. Chenran Wang
8. Yuan Zhang

In Molecular Biology

1. I. Samish
2. Chun-chao Lo
3. Xiuwen Liu
4. Wei Wu
5. Jinfeng Zhang
6. Yang Chen
7. Chenran Wang
8. Yuan Zhang

Citations in the corpus

• ProDCoNN: Protein design using a convolutional neural network (2019, methodology): “Significant progress in CPD has been made in the past few decades 1 such as enzymes design 2-8 and membrane protein design.”
• Emerging themes in the computational design of novel enzymes and protein–protein interfaces (2013, background): “Constellations of backbones that can support the theozyme model are searched among hundreds of small-molecule binding pockets in crystallographic protein structures [23,34].”
• Achievements and Challenges in Computational Protein Design. (2017, methodology): “In 2012 the Mayo lab published an interesting story of applying an iterative stepwise approach to computational enzyme design of Kemp eliminases termedHG-1,HG-2, andHG-3 [100].”