MicroRNA biogenesis pathways in cancer
By Shuibin Lin, Richard I. Gregory. Nature Reviews. Cancer, 2015
2,019 citations recorded by the source corpus.
MicroRNAs (miRNAs) are critical regulators of gene expression. Amplification and overexpression of individual 'oncomiRs' or genetic loss of tumour suppressor miRNAs are associated with human cancer and are sufficient to drive tumorigenesis in mouse models. Furthermore, global miRNA depletion caused by genetic and epigenetic alterations in components of the miRNA biogenesis machinery is oncogenic. This, together with the recent identification of novel miRNA regulatory factors and pathways, highlights the importance of miRNA dysregulation in cancer.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/18770923b95dbd9033c7f3d69f362f28faa51ee0
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In Cancer Research
In Molecular Biology
- Angela L. Riffo-Campos
- Priscilla Brebi-Mieville
- Jianguo Xia
- I. Riquelme
- David S. Wishart
- Jasmine Chong
- Igor Sinelnikov
Citations in the corpus
- miRNAs as Biomarkers in Disease: Latest Findings Regarding Their Role in Diagnosis and Prognosis (2020, background): “Lastly, the alteration of circulating miRNAs in cancer could also be caused by transcriptional errors of pri-miRNA [119].”
- RNA-Binding Proteins in Cancer: Old Players and New Actors. (2017, background): “DICER1 encodes a cytoplasmic endoribonuclease that processes small precursor RNA molecules into mature forms, a central step in the miRNA and RNA interference biogenesis pathways [14].”
- Tools for Sequence-Based miRNA Target Prediction: What to Choose? (2016, background): “Conversely, tumor-suppressor miRNAs repress the expression of genes with oncogenic functions [13].”
- miRNet - dissecting miRNA-target interactions and functional associations through network-based visual analysis (2016, background): “Their deregulations have been reported in a wide array of complex diseases such as cardiovascular diseases, type 2 diabetes, neurological disorders and multiple types of cancers (2).”