Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice

By Marc Schneeberger, A. Everard, A. Gómez-Valadés, S. Matamoros, Sara Ramírez, N. Delzenne, R. Gomis, M. Claret, Patrice D Cani. Scientific Reports, 2015

732 citations recorded by the source corpus.

Recent evidence indicates that the gut microbiota plays a key role in the pathophysiology of obesity. Indeed, diet-induced obesity (DIO) has been associated to substantial changes in gut microbiota composition in rodent models. In the context of obesity, enhanced adiposity is accompanied by low-grade inflammation of this tissue but the exact link with gut microbial community remains unknown. In this report, we studied the consequences of high-fat diet (HFD) administration on metabolic parameters and gut microbiota composition over different periods of time. We found that Akkermansia muciniphila abundance was strongly and negatively affected by age and HFD feeding and to a lower extend Bilophila wadsworthia was the only taxa following an opposite trend. Different approaches, including multifactorial analysis, showed that these changes in Akkermansia muciniphila were robustly correlated with the expression of lipid metabolism and inflammation markers in adipose tissue, as well as several circulating parameters (i.e., glucose, insulin, triglycerides, leptin) from DIO mice. Thus, our data shows the existence of a link between gut Akkermansia muciniphila abundance and adipose tissue homeostasis on the onset of obesity, thus reinforcing the beneficial role of this bacterium on metabolism.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/185717da1392520319f5a8b10415410b6956c127

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. Patrice D Cani
2. W. D. de Vos
3. J. Durack
4. S. Lynch

In Physiology

1. W. D. de Vos
2. Patrice D Cani

Citations in the corpus

• Targeting the Microbiota-Gut-Brain Axis: Prebiotics Have Anxiolytic and Antidepressant-like Effects and Reverse the Impact of Chronic Stress in Mice. (2017, unknown): “has received a lot of attention for its beneficial role for the host like protection from diet-induced obesity, insulin resistance, intestinal inflammation (44-46), gut barrier impairment (47) and was”
• Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila (2017, background): “Since its discovery in 2004, numerous studies have mostly linked the abundance of A. muciniphila with beneficial effects, and this although very few exceptions exist in specific non-physiological models (i.e., gnotobiotic models, specific immune double knockout models) (Seregin et al., 2017).”
• The gut microbiome: Relationships with disease and opportunities for therapy (2018, background): “Conversely, an abundance of a mucin-degrading gut bacteria, Akkermansia muciniphila, is associated with increased metabolic health in obese patients (Dao et al., 2016) and in mice fed a HFD (Schneeberger et al., 2015).”