Integrin-based Therapeutics: Biological Basis, Clinical Use and New Drugs

By Klaus Ley, J. Rivera-Nieves, W J Sandborn, S. Shattil. Nature reviews. Drug discovery, 2015

934 citations recorded by the source corpus.

The three endogenous gaseous transmitters — nitric oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S) — regulate a number of key biological functions. Emerging data have revealed several new mechanisms for each of these three gasotransmitters in tumour biology. It is now appreciated that they show bimodal pharmacological character in cancer, in that not only the inhibition of their biosynthesis but also elevation of their concentration beyond a certain threshold can exert anticancer effects. This Review discusses the role of each gasotransmitter in cancer and the effects of pharmacological agents — some of which are in early-stage clinical studies — that modulate the levels of each gasotransmitter. A clearer understanding of the pharmacological character of these three gases and the mechanisms underlying their biological effects is expected to guide further clinical translation.

Subfields: Biochemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/18270983d9bf970de6fd59a7069ad42ee6d310dc

Citations in the corpus

• Integrin Signaling in Cancer: Mechanotransduction, Stemness, Epithelial Plasticity, and Therapeutic Resistance (2019, neutral): “for the prevention of thrombosis or the treatment of inflammation, respectively (Ley et al., 2016).”