3D Printing of Scaffolds for Tissue Regeneration Applications
By Anh‐Vu Do, Behnoush Khorsand, S. Geary, A. Salem. Advanced Healthcare Materials, 2015
842 citations recorded by the source corpus.
The current need for organ and tissue replacement, repair, and regeneration for patients is continually growing such that supply is not meeting demand primarily due to a paucity of donors as well as biocompatibility issues leading to immune rejection of the transplant. In order to overcome these drawbacks, scientists have investigated the use of scaffolds as an alternative to transplantation. These scaffolds are designed to mimic the extracellular matrix (ECM) by providing structural support as well as promoting attachment, proliferation, and differentiation with the ultimate goal of yielding functional tissues or organs. Initial attempts at developing scaffolds were problematic and subsequently inspired an interest in 3D printing as a mode for generating scaffolds. Utilizing three‐dimensional printing (3DP) technologies, ECM‐like scaffolds can be produced with a high degree of complexity, where fine details can be included at a micrometer level. In this Review, the criteria for printing viable and functional scaffolds, scaffolding materials, and 3DP technologies used to print scaffolds for tissue engineering are discussed. Creating biofunctional scaffolds could potentially help to meet the demand by patients for tissues and organs without having to wait or rely on donors for transplantation.
Subfields: Biomedical Engineering, Surgery
View Paper: https://www.semanticscholar.org/paper/181fe00b0c0ed5bdf24c00e4fa44e0370d316a09
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Citations in the corpus
- Research status of laser additive manufacturing for metal: A review (2021, background): “[17] Do AV, Khorsand B, Geary SM, Salem AK.”
- Is It Time to Start Transitioning From 2D to 3D Cell Culture? (2020, background): “3D printing has also allowed the printing of complex ECMlike scaffolds with such control that details can be fine-tuned at the micrometer level (Do et al., 2015).”
- 3D bioactive composite scaffolds for bone tissue engineering (2017, methodology): “Porosity can also be added to composite polymerceramic scaffolds with varying levels of precision using techniques including 3D printing [80] and electrospinning [127,195].”
- Polycaprolactone as biomaterial for bone scaffolds: Review of literature. (2020, positive): “3D printing Three-dimensional printing has evolved as a promising technology to fabricate scaffolds and complex structures with micron size precision and accuracy with homogenous distribution of cells within it.(27) Recently, Cho et al.”