Efficacy of minocycline in patients with amyotrophic lateral sclerosis: a phase III randomised trial.

By P. Gordon, D. Moore, Robert G. Miller, J. Florence, J. Verheijde, Carolyn Doorish, J. Hilton, G. Spitalny, R. MacArthur, H. Mitsumoto and 10 more. Lancet Neurology, 2007

653 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Genetics, Neurology

View Paper: https://www.semanticscholar.org/paper/180b75160a7a9968205d49945db39647b610c4e3

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Richard M. Myers
2. V. Subbiah
3. Elaine R. Mardis

In Neurology

1. V. Subbiah
2. M. Conrad

Citations in the corpus

• Mechanisms Underlying Inflammation in Neurodegeneration (2010, critical): “An important case in point is provided by the anti-inflammatory drug minocycline, which delayed disease progression in an ALS transgenic mouse model but worsened disease symptoms in phase III clinical trials in ALS patients (Gordon et al., 2007; Kriz et al., 2002), suggesting that the transgenic mod”
• Minocycline selectively inhibits M1 polarization of microglia (2013, background): “the survival of individuals with ALS in either a mouse model or human clinical cases.(19,20) Nevertheless, minocycline is a commonly used, strong inhibitor of microglial”
• Minocycline: far beyond an antibiotic (2013, background): “Amyotrophic lateral sclerosis patients treated with the drug deteriorated significantly faster than patients in the control group (Gordon et al., 2007).”
• Accelerated clinical discovery using self-reported patient data collected online and a patient-matching algorithm (2011, background): “However, minocycline was subsequently found to accelerate disease progression when tested in a multicenter randomized placebo-controlled phase 3 tria”
• Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration (2017, background): “Ferroptosis, a newly identified oxidative cell death mechanism triggered by massive lipid peroxidation, is implicated in the degeneration of neurons populations such as spinal motor neurons and midbrain neurons.”
• A neurodegeneration-specific gene expression signature and immune profile of acutely isolated microglia from an ALS mouse model (2013, positive): “Nonspecific anti-inflammatory drugs, such asminocycline, would negate both of these aspects of microglia, and may explain past failures in clinical trials (Gordon et al., 2007).”
• A comprehensive review of amyotrophic lateral sclerosis (2015, background): “Mitochondrial impairment and aberrant calcium handling are two major components of motor neuron injury that lead to activation of the apoptotic cascade[58,141] Dexpramipexole (R−(+) pramipexole)[45] Minocycline[104] Pentoxifylline[192] Omigapil (TCH-346)[200] Caspase family inhibitor (fluoromethylke”