Reassessing pattern separation in the dentate gyrus

By Adam Santoro. 2013

107 citations recorded by the source corpus.

The dentate gyrus (DG) is postulated to be a “pattern separator” (Marr, 1971; Rolls, 1989a,b, 1990; Treves and Rolls, 1994). Yet, the definition of pattern separation has become a haze, with researchers using the term interchangeably to describe computational processes, changes in cell ensemble activity, and even behavioral phenomena (Leutgeb et al., 2007; McHugh et al., 2007; Clelland et al., 2009; Bakker et al., 2010). To accurately assess the large influx of papers purporting to attribute pattern separation to the DG, the concept must be reassessed; the original definition of pattern separation as a computational process and its newer, colloquial definition as a form of behavioral context discrimination must be accurately parsed if relations between the data are to be made.

Subfields: Cognitive Neuroscience

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Citations in the corpus

Re-evaluating circuit mechanisms underlying pattern separation (2019, neutral): “Such behavioural assays of pattern separation (sometimes called ‘behavioural pattern separation’) are not necessarily equivalent to the computational process of separating input patterns (Figure 1B) (Santoro, 2013).”
CA3 Retrieves Coherent Representations from Degraded Input: Direct Evidence for CA3 Pattern Completion and Dentate Gyrus Pattern Separation (2014, background): “Because pattern separation and pattern completion, by definition, require knowledge of the transformation of an input representation to an output representation (Guzowski et al., 2004;McClelland andGoddard, 1996; O’Reilly and McClelland, 1994; Santoro, 2013), it is impossible to know whether the out”
Tracking the Flow of Hippocampal Computation: Pattern Separation, Pattern Completion, and Attractor Dynamics (2015, methodology): “(For more detailed reviews, see Rolls & Kesner, 2006; Yassa & Stark, 2011; Santoro, 2013.)”
Tonic Inhibitory Control of Dentate Gyrus Granule Cells by α5-Containing GABAA Receptors Reduces Memory Interference (2015, background): “Thus, the above tests do not comprise direct tests of the computational concept of pattern separation, and it has been disputed whether it is at all possible to have a direct behavioral test of this concept (see discussions by Aimone et al., 2011; Santoro, 2013).”
Pattern separation in the hippocampus through the eyes of computational modeling (2017, methodology): “Since there are several excellent reviews on pattern separation in general (Leutgeb & Leutgeb, 2007; Santoro, 2013; Schmidt et al., 2012; Yassa & Stark, 2011), we focus on presenting and discussing the different theoretical approaches and computational models that have examined the pattern…”
Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity (2016, background): “Theoretical models refer to those processes as pattern separation and pattern completion, respectively (Marr, 1971; Treves and Rolls, 1994; Yassa and Stark, 2011; Santoro, 2013).”