The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs

By Naokazu Inoue, M. Ikawa, A. Isotani, M. Okabe. Nature, 2005

780 citations recorded by the source corpus.

Subfields: Food Science, Public Health, Environmental and Occupational Health, Reproductive Medicine

View Paper: https://www.semanticscholar.org/paper/178ccf3a128d0de63b235fd45e79b40a291d6ae1

How researchers see this paper

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1. H. McMahon
2. S. Martens
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4. Shaogeng Tang
5. J. Amory
6. Yonggang Lu
7. W. Bremner
8. William M. Skinner

Citations in the corpus

• Human sperm TMEM95 binds eggs and facilitates membrane fusion (2022, background): “Sperm IZUMO1 (1) and 63 egg JUNO (2) mediate the only known cell surface interaction between mammalian 64 gametes.”
• Advances in male contraception. (2008, background): “Data suggest that Izumo is required for sperm-egg fusion (368).”
• Mechanisms of membrane fusion: disparate players and common principles (2008, background): “, and IZUMO , a single transmembrane-domain protein with an extracellular immunoglobulin (Ig)-like domain on the sperm surfac”