Non-viral vectors for gene-based therapy

By Hao Yin, Rosemary L Kanasty, Ahmed A. Eltoukhy, A. Vegas, J. R. Dorkin, Daniel G. Anderson. Nature reviews genetics, 2014

2,860 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/177c49cd659314d010e042020300dfa6c65a2176

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Citations in the corpus

The delivery of therapeutic oligonucleotides (2016, background): “A key issue for the future is whether the CRISPRCas9 gene editing approach will move from its current reliance on viral vectors to greater use of non-viral delivery systems and thus benefit from the technologies developed for oligonucleotide delivery (162,342).”
In vitro and ex vivo strategies for intracellular delivery (2016, methodology): “In the reported modalities thus far, the target material is delivered through one of three modes: (1) dissociation from the penetrating structure upon cytosolic entry82,83; (2) direct injection through a hollow nanoneedle or “nanostraw”84,85 or (3) the diffusion from the extracellular medium through”
Gene therapy clinical trials worldwide to 2017: An update (2018, background): “The comparative strengths of nonviral approaches include ease of chemical characterisation, simplicity and reproducibility of production, larger packaging capacity, and reduced biosafety concerns.(117) Gene delivery, however, is relatively inefficient compared to recombinant viral systems and the ef”
Plant exosome like nanovesicles: Emerging therapeutics and drug delivery nanoplatforms. (2020, background): “However, such vectors typically have the innate risks of immunogenicity and toxicity.(148,149) Although PELNVs are neophytes in the arena of gene delivery, they provide a solution to aforementioned complications and also go a notch above by traversing stringent biological barriers such as the BBB.”
Inferring Biological Networks by Sparse Identification of Nonlinear Dynamics (2016, background): “Breakdown of the function and control circuits of such networks can lead to cancer and other deadly diseases, motivating therapeutic gene modulation or pharmaceutical intervention [6], [7].”