From "Simple" DNA-Protein Interactions to the Macromolecular Machines of Gene Expression

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Quantifying absolute protein synthesis rates reveals principles underlying allocation of cellular resources. (2014, background): “Thus, although higher concentrations of any given TF would allow it to find its cognate DNA sites more rapidly (von Hippel, 2007), too many TFs in total would mask binding sites.”
Intermittent search strategies (2011, background): “The pioneering studies on facilitated diffusion (Berg et al., 1981; Riggs et al., 1970; Winter et al., 1981; Winter and Von Hippel, 1981) are based on ensemble measurements, which were for a long time the only way to experimentally access to protein/DNA interaction.”