Genomewide selection when major genes are known

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Genomic Selection for Quantitative Adult Plant Stem Rust Resistance in Wheat (2014, result): “Our inding that modeling selected markers as ixed efects in G-BLUP leads to improved accuracy over standard G-BLUP agrees with a recent simulation study (Bernardo, 2013) which found modeling a large-efect locus as ixed to be advantageous when heritability of the trait was >0.”
Perspectives for Genomic Selection Applications and Research in Plants (2015, background): “However, (Bernardo, 2013) showed in simulations that it is beneficial to fit the known QTLs as fixed effects only when they each explain more than 10% of the genetic variance.”