A chemosensory system that regulates biofilm formation through modulation of cyclic diguanylate levels.

By J. W. Hickman, D. Tifrea, C. Harwood. Proceedings of the National Academy of Sciences of the United States of America, 2005

844 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/1723136c9a8e85ea48c0a199b2f1a96bf313e735

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Citations in the corpus

Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence (2017, background): “A cascade of phosphorylations is triggered upon surface attachment and possibly sensing mechanical stress or other environmental stimuli which then activate the cyclic di-GMP synthesizing protein WspR promoting biofilm formation (Hickman et al., 2005; Porter et al., 2011).”
CONSEJO SUPERIOR DE INVESTIGACIONES CIENTÍFICAS (2009, background): “, 2008) y BPs (Hickman et al., 2005; Gjermansen et al., 2006; Kuchma et al., 2007; Nakhamchik et al., 2008), confieren una morfología de colonia rugosa (Simm et al.”
Signals, Regulatory Networks, and Materials That Build and Break Bacterial Biofilms (2009, background): “For example, deletion of wspF, encoding a homolog of the methylesterase CheB, which is involved in adaptation to chemotactic stimuli, leads to increases in cellular c-di-GMP levels, transcription of exopolysaccharide synthesis genes, and biofilm formation (133).”
Assembly and Development of the Pseudomonas aeruginosa Biofilm Matrix (2009, background): “The level of intracellular cyclic-di-guanylate controls the production of Psl and Pel exopolysaccharide [32,33].”
Strategies for combating bacterial biofilms: A focus on anti-biofilm agents and their mechanisms of action (2017, background): “However, at higher density these structures are larger forming aggregates up to diameter of 1000mm. Extracellular polysaccharide intracellular adhesin (referred as polymers of b 1–6 N-acetylglucosamine or PNAG after determination of the chemical structure),69 and spa encoding Protein A are reported ”
Bacterial Extracellular Polysaccharides in Biofilm Formation and Function (2015, background): “As with Pel, high expression of Psl in this strain is due to elevated levels of the second messenger cyclic di-GMP (65, 68, 69).”
Identification of FleQ from Pseudomonas aeruginosa as a c-di-GMP-responsive transcription factor (2008, methodology): “aeruginosa results in a wrinkled colony morphology (Friedman and Kolter, 2004a,b; Hickman et al., 2005; Sakuragi and Kolter, 2007).”