Immunological considerations for COVID-19 vaccine strategies

By M. Jeyanathan, S. Afkhami, F. Smaill, Matthew S. Miller, B. Lichty, Z. Xing. Nature reviews. Immunology, 2020

926 citations recorded by the source corpus.

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to humanity in a century. It is widely believed that prepandemic normalcy will never return until a safe and effective vaccine strategy becomes available and a global vaccination programme is implemented successfully. Here, we discuss the immunological principles that need to be taken into consideration in the development of COVID-19 vaccine strategies. On the basis of these principles, we examine the current COVID-19 vaccine candidates, their strengths and potential shortfalls, and make inferences about their chances of success. Finally, we discuss the scientific and practical challenges that will be faced in the process of developing a successful vaccine and the ways in which COVID-19 vaccine strategies may evolve over the next few years. This Review outlines the guiding immunological principles for the design of coronavirus disease 2019 (COVID-19) vaccine strategies and analyses the current COVID-19 vaccine landscape and the challenges ahead.

Subfields: Health, Immunology, Infectious Diseases

View Paper: https://www.semanticscholar.org/paper/16fc28ea3180128d4cd690ef4a4ca74ac1ba01f4

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

  1. Shugang Qin
  2. Min Wu
  3. Wen Xiao
  4. Qian Zheng
  5. Na Fan
  6. Ke-Ke Chen
  7. Xiaoshan Tang
  8. Yuting Chen

Citations in the corpus