Zebrafish as an emerging model for studying complex brain disorders

By A. Kalueff, A. Stewart, R. Gerlai. TIPS - Trends in Pharmacological Sciences, 2014

1,066 citations recorded by the source corpus.

The zebrafish (Danio rerio) is rapidly becoming a popular model organism in pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently used to increase our understanding of brain function, dysfunction, and their genetic and pharmacological modulation. Here we review the developing utility of zebrafish in the analysis of complex brain disorders (including, for example, depression, autism, psychoses, drug abuse and cognitive disorders), also covering zebrafish applications towards the goal of modeling major human neuropsychiatric and drug-induced syndromes. We argue that zebrafish models of complex brain disorders and drug-induced conditions have become a rapidly emerging critical field in translational neuropharmacology research.

Subfields: Cell Biology, Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/16d43bbb6ba80bb65fc2de1e2b789adc9d51e210

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Citations in the corpus

• Crossing the blood‐brain barrier with nanoparticles (2018, background): “Zebrafish is a vertebrate species fish with high similarity to humans regarding physiological and genetic homology [108].”