In-feed antibiotic effects on the swine intestinal microbiome

By T. Looft, T. Johnson, Heather K. Allen, D. Bayles, D. Alt, Robert D. Stedtfeld, W. Sul, Tiffany M. Stedtfeld, Benli Chai, James R. Cole and 3 more. Proceedings of the National Academy of Sciences of the United States of America, 2012

948 citations recorded by the source corpus.

Subfields: Infectious Diseases, Molecular Biology, Pollution

View Paper: https://www.semanticscholar.org/paper/16cfd230fa4b6ecad2e0c2977b19c70c2a284a10

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Citations in the corpus

Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH (2013, background): “Possible causes for elevated Escherichia include special dietary components, as suggested by a recent report that subtherapeutic doses of antibiotics leads to increased Escherichia in swine gut microbiomes.(49) Microbiomes in patients with NASH may offer a unique opportunity for interrupting disease”
Review of antibiotic resistance in China and its environment. (2018, positive): “Livestock waste has been shown to be a hotspot of antibiotic residues that can a ﬀ ect the gut microbiota of animals and perpetuate the increased prevalence of antibiotic resistance in bacteria in manure (Langford et al., 2003; Looft et al., 2012; Witte, 2000).”
Using the class 1 integron-integrase gene as a proxy for anthropogenic pollution (2014, background): “can be analysed (Looft et al., 2012; Zhu et al., 2013), allowing more comprehensive spatial and temporal studies.”
Antibiotic resistome in the livestock and aquaculture industries: Status and solutions (2020, background): “A wide array of ARGs present in diverse bacterial hosts has been found in animal guts and manure, and ARG prevalence can clearly be linked to the use of antibiotics or other selecting agents in animals (Looft et al., 2012; Van Boeckel et al., 2019; Zhao et al., 2018).”
Metagenomic and network analysis reveal wide distribution and co-occurrence of environmental antibiotic resistance genes (2015, background): “High-capacity quantitative PCR arrays have been applied to detect ARGs in manure, compost and soil (Looft et al., 2012; Zhu et al., 2013) to overcome the capacity limitations; however, it cannot overcome the other drawbacks mentioned above.”
The Potential Use of Probiotics to Improve Animal Health, Efficiency, and Meat Quality: A Review (2020, background): “The commensal (indigenous) gut microbiota plays important roles in the animal’s overall health, growth and development, and productivity through promotion of immune system development and response and facilitating nutrient extraction from the diet [26].”
Environmental Escherichia coli: ecology and public health implications—a review (2017, background): “coli commonly resides in the intestines of warmblooded animals, it is subjected to frequent encounters with antibiotics, providing it with high selection pressure leading to resistance against antibiotics consumed by its host (Looft et al. 2012).”
Antibiotics and the gut microbiota. (2014, positive): “Genes conferring resistance to classes of drugs that were not present in the feed source, such as aminoglycoside resistance genes, were also enriched, providing evidence for the role of antibiotics in promoting resistance to unrelated classes of drugs in commensal microbes (28).”
Antibiotic-Induced Changes in the Intestinal Microbiota and Disease. (2016, background): “Subsequently, their microbiota showed increased expression of ARGs, conferring tolerance even to drugs that were not administered during the study [101].”
Antimicrobial use in aquaculture re-examined: its relevance to antimicrobial resistance and to animal and human health. (2013, background): “…lysis, as well as that mediated by plasmids in the aquatic environment and in the intestines of fish and terrestrial animals (Stewart and Sinigalliano, 1990; Beaber et al., 2004; Frost et al., 2005; Aarestrup et al., 2008; Allen et al., 2011; Domingues et al., 2012; Looft et al., 2012).”