Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease.

By Matthew R. Alexander, G. Owens. Annual Review of Physiology, 2012

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Epigenetic Modifications: Basic Mechanisms and Role in Cardiovascular Disease (2013 Grover Conference Series) (2014, background): “Epigenetic regulation controls vascular smooth muscle phenotype in health and disease.(38) Archer and colleagues(39) have also shown that epigenetic attenuation of mitochondrial superoxide dismutase (SOD2) expression leads to pulmonary”
Vascular smooth muscle cells in atherosclerosis (2016, background): “VSMCs in culture and in atherosclerosis reduce expression of these markers, and, at least in vitro, acquire increased capacity for cell proliferation, migration, and secretion of various extracellular matrix (ECM) proteins and cytokines.(13) VSMCs undergoing phenotypic switching can also acquire mac”
The vascular smooth muscle cell in arterial pathology: a cell that can take on multiple roles. (2012, background): “Regulation of the expression level of these transcription factors drives the effects of antiproliferative molecules such as adiponectin, TGF-b, and peroxisome proliferator-activated receptor gamma (PPAR-g).34 miRs dynamically regulate VSMC differentiation and phenotypic switching. miR-143/145, miR-2”