A high proportion of leucine is required for optimal stimulation of the rate of muscle protein synthesis by essential amino acids in the elderly.

By C. Katsanos, Hisamine Kobayashi, M. Sheffield-Moore, A. Aarsland, R. Wolfe. American Journal of Physiology. Endocrinology and Metabolism, 2006

937 citations recorded by the source corpus.

Subfields: Cell Biology, Orthopedics and Sports Medicine, Physiology

View Paper: https://www.semanticscholar.org/paper/15d60e7abc802cea70acc1bfc8047bc8516a19af

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. R. A. Saxton
2. Lynne Chantranupong
3. David M. Sabatini

In Physiology

1. David M. Sabatini
2. R. A. Saxton

Citations in the corpus

• Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group (2014, result): “A higher proportion of leucine was required for optimal stimulation of the rate of muscle protein synthesis in older adults, as compared to younger adults [57].”
• Sestrin2 is a leucine sensor for the mTORC1 pathway (2015, background): “Leucine attenuates the decrease in skeletal muscle protein synthesis that occurs in the elderly and stimulates satiety (1, 37).”